Understanding how bacteria develop into one of the toughest cell types on Earth
Research in the Rodrigues lab is focused on understanding how bacteria develop into one of the toughest cell types on Earth - Spores.
Spores are dormant, highly-resistant cells that allow bacteria to persist in the environment. Spores are inert to antibiotics and resist common sterilisation methods that kill actively growing bacteria. In the right conditions, spores germinate and generate new populations of bacteria. Some spore-forming bacteria cause disease in humans, animals and insects, and contaminate food sources. The Rodrigues lab is interested in the molecular processes that underlie the process of how bacteria develop into spores. Currently, our research examines these processes in the model bacterium Bacillus subtilis and we will soon be launching projects exploring the sporulation biology of the human pathogen Clostridioides difficile.
Our most recent work is now published in PLOS Genetics and Developmental Cell. Our recent collaborative work with Erdem Karatekin at Yale University is now published in PLOS Biology. Click links (in bold) for more details.